Work Package 5 - Specific clinical trials on existing and sporadic zoonotic diseases
Richard Kock & colleagues conducting a necropsy on a Mass Mortality event in wildlife affecting saiga antelope in 2017
Work Package 5 of the PANDORA ID NET is led by the Royal Veterinary College, London and will include an in situ needs assessment on key zoonoses in the participant countries, where there will be contemporary identification of key gaps and opportunities from which the clinical trials will be designed. This will include 4-6 zoonoses and 4-6 gaps and opportunities in 2-3 partner countries. This process will be undertaken jointly with Work Package 4 led by SUA/SACIDs to ensure synergy and enhanced outcomes. The clinical trials will then be implemented in partner countries including working with joint teams from the appropriate sectors in animal and human health. Once complete the data will be collated from trials and analysed. Results will be disseminated through to private sector, funders, health NGOs, academic communities, and government for policy development and role-out of interventions working closely with Work Package 7.
Advances in understanding of the contextual drivers of disease emergence, whether linked to environmental changes, socioecology of the hosts, development or socioeconomic factors is changing the focus of health services and preventive measures for disease. Genomics and proteomics have helped us better understand mechanisms of pathogenesis, host immunity, and drug resistance and are helping us identify new drug targets and develop new vaccines and diagnostics. Progress in synthetic chemistry, robotics, and computer modeling are leading to advances in drug design, high-throughput screening, and predictive models of disease transmission. Developments in molecular and genetic epidemiology are helping us understand pathogen virulence, transmission patterns, and host susceptibility.
A range of trials on evaluation of novel preventive or control measures will be initiated, based on the following tools; behavioural modification, shifting of development strategies, attention to environmentally driven infection, socioecological and economic factors identified, and including application of relevant medical technologies such as rapid diagnostics, biomarkers and, novel treatments or vaccines prioritised.
Royal Veterinary College support for the rinderpest eradication programme in South Sudan
'One Health' training in Rwanda provided by Richard Kock and the Royal Veterinary College.